Supported by the Department of Medical Services of the Ministry of Public Health of Thailand, the 2nd APTOS Big Data Competition focuses on the prediction of anti-VEGF treatment outcomes based on tens of thousands of OCT images of patients’ eyes taken at baseline and at 6 months after the loading treatment.


Anti-VEGF treatments are a group of medicines which reduce new blood vessel growth or swelling and can be used to treat a number of eye conditions that cause neovascularization or edema under the macular area of your retina at the back the eyes. However, a substantial number of patients do not respond to this therapy or do so to an inadequate degree. Those calculations have been reported to range from 10% to 50% depending on the study, despite receiving monthly injections of anti-VEGF therapies. Imagine you can identify non-responders before treatment and tailor individualized treatment plans for them.
In this synchronous competition, you will build a machine learning model to predict treatment response of patients with diabetic maculopathy, including age-related macular degeneration (AMD), diabetic macular edema (DME) and polypoidal choroidal vasculopathy (PCV). You will work with thousands of images collected in hospital settings to help predict patients’ response to anti-VEGF treatments.

  • August 28, 2021 – Launch of Competition
  • September 1, 2021 – Accepting Submissions
  • November 19, 2021 – Entry Deadline, Team Merger Deadline & Preliminary Round Submission Deadline
  • December 31, 2021 – Final Submission Deadline (Only the top 100 teams in the preliminary can get through to the final.)
  • January 21, 2022Code Defense (The top 5 finalists will be challenged by the panel after code review.)
  • February 12, 2022Prize Presentation


Cash Prizes

Participants with the best scores on the private leaderboard are eligible to receive:

  • 1st Place – US$8,000
  • 2nd Place – US$5,000
  • 3rd Place – US$2,000

Additional Opportunities:
Winners in this competition will be invited to contribute to the APTOS Monthly Webinar on February 12, 2022. All winners must present in the “Share & Tell” session on February 12 in order to become eligible for the cash prizes.



We thank Aravind Eye Hospitals, Rajavathi Hospital, Rhaiking Hospital and Zhongshan Ophthalmic Center for providing the images for the 2nd APTOS Big Data Competition.
We are also grateful towards Alibaba Cloud and Tianchi, our sole sponsors that provide us with the technical support necessary for the Competition to take place.